This monograph is a condensed form of the fundamental knowledge on the named reaction ¿Prins cyclization¿ in organic synthesis. This monograph consists of three distinct chapters: chapter 1 provides detailed description of the Prins cyclization, contemporary approaches to the synthesis of chiral 1,3-diol units and application to the total synthesis of biologically active natural products; chapter 2 describes the historical and biological background of the naturally occurring, cytotoxic 14-membered macrolide (+)-Neopeltolide, including their isolations, structural elucidation and previous synthetic approaches and my synthetic route to the total synthesis of (+)-Neopeltolide macrolactone, while chapter 3 provides information on the use of Prins cyclization for the synthesis of 4-iodo, 4-amido, 4-azidotetrahydropyran derivatives. This monograph is an indispensable reference for any chemist working with tetrahydropyran, dihydropyran and piperidine containing natural products.
Dr.Gunda Gopala Krishana Satya Narayana Kumar was born in Yarrampalli-AP,India in 1981 and received his Ph.D degree on the Prins Cyclization under the supervision of Dr. J. S. Yadav,FNA,FNASc,FTWAS at the IICT,India. He conferred with the "Best Senior Research Fellow Award" in 2007 and "Dr.K.V.Rao Scientific Society-Young Scientist Award" in 2010.