Optimizaciq sostawa nanochastic piridostigmina
Niwash , Kumar & Nitish Kumar , Singh
Optimizaciq sostawa nanochastic piridostigmina
Niwash , Kumar & Nitish Kumar , Singh
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Description
Cel'ü ätoj knigi qwlqetsq podgotowka nanochastic piridostigmina dlq kontrolq wyswobozhdeniq piridostigmina dlq uluchsheniq peroral'noj biodostupnosti, powysheniq rastworimosti i skorosti rastworeniq za schet umen'sheniq razmera chastic lekarstwennogo sredstwa. Infrakrasnye spektroskopicheskie issledowaniq podtwerdili otsutstwie wzaimodejstwiq mezhdu lekarstwennym sredstwom i polimerami. Nanochasticy piridostigmina s kontroliruemym wyswobozhdeniem poluchali putem wypariwaniq rastworitelq s ispol'zowaniem ätilcellülozy, hitozana i HPMC K100 w razlichnyh sootnosheniqh. Vyhod produkcii prigotowlennyh nanochastic s kontroliruemym wyswobozhdeniem (ot F1 do F16) nahoditsq w diapazone ot 76,11 % do 83,58 %. Soderzhanie lekarstwennogo sredstwa w sostawe nanochastic s kontroliruemym wyswobozhdeniem (ot F1 do F16) nahoditsq w diapazone ot 82,56% do 98,20%. Teoreticheskaq zagruzka prigotowlennyh nanochastic s kontroliruemym wyswobozhdeniem (F1-F16) nahoditsq w diapazone ot 24,43 % do 64,24 %. Jeffektiwnost' ulawliwaniq uwelichiwalas' s uwelicheniem koncentracii polimerow, i sostawy, soderzhaschie nanochasticy hitozana F6 (1:2), prodemonstrirowali luchshee ulawliwanie (90,94%) sredi wseh sostawow.
Niwash Kumar currently working as Assistant Professor at Kurma sanskriti institute of pharmaceutical science) affiliated to Aryabhata acknowledge University Patna Bihar. Nitish Kumar Singh currently working as Research Associate a VIT university one of the prestigious institution with NIRF ranking 7 in this year 2022.
Niwash Kumar currently working as Assistant Professor at Kurma sanskriti institute of pharmaceutical science) affiliated to Aryabhata acknowledge University Patna Bihar. Nitish Kumar Singh currently working as Research Associate a VIT university one of the prestigious institution with NIRF ranking 7 in this year 2022.