Oscar

1. Jordi H. Borrell
2. Òscar Domènech
3. Kevin M.W. Keough

Membrane Protein – Lipid Interactions: Physics and Chemistry in the Bilayer

This book has been conceives as a brief introduction to biomembranes physical chemistry for undergraduate students of sciences, and it is particularly dedicated to the lipid-protein membrane interactions.

Glycoscience and Microbial Adhesion

bacterial carbohydrate recognition are conveyed, covering Gram-positive as well as Gram-negative bacteria, in Chapter 4 Streptococci and Staphylococci, and in Chapter 5, carbohydrate binding specificities of Helicobacter pylori. In Chapter 6, "Bitter sweetness of complexity," the collected reflections on mic- bial adhesion are expanded by a perspective on a broader impact of glycosylation on cellular adhesion, motility and regulatory processes, paralleling the complexity of N-glycan structures on cell surfaces. It highlights particularly how structural details of N-glycans have been causally related to pathological scenarios, with a focus on ?(1,6)-N-acetylglucosaminyltransferase. In the final chapter, biofilm formation is reviewed, covering knowledge about structure and biosynthesis of polysaccharide intercellular adhesins (PIAs) which are central to biofilm formation. This comprehensive chapter explains all PIA-related principles of medical device-associated infections. It is our hope, that this collection of expert articles, ranging from structural ch- istry and structural biology to biochemistry and medicine, will be a stimulation and motivation for our colleagues in the life sciences. At the same time, we hope that these reflections on microbial adhesion will awake interest in and promote und- standing of the complex processes associated with the glycocalyx and the multif- eted interactions between the host cell and its "guest," as well as the biological consequences resulting from this mutual interplay.

Glycoscience and Microbial Adhesion

bacterial carbohydrate recognition are conveyed, covering Gram-positive as well as Gram-negative bacteria, in Chapter 4 Streptococci and Staphylococci, and in Chapter 5, carbohydrate binding specificities of Helicobacter pylori. In Chapter 6, "Bitter sweetness of complexity," the collected reflections on mic- bial adhesion are expanded by a perspective on a broader impact of glycosylation on cellular adhesion, motility and regulatory processes, paralleling the complexity of N-glycan structures on cell surfaces. It highlights particularly how structural details of N-glycans have been causally related to pathological scenarios, with a focus on ?(1,6)-N-acetylglucosaminyltransferase. In the final chapter, biofilm formation is reviewed, covering knowledge about structure and biosynthesis of polysaccharide intercellular adhesins (PIAs) which are central to biofilm formation. This comprehensive chapter explains all PIA-related principles of medical device-associated infections. It is our hope, that this collection of expert articles, ranging from structural ch- istry and structural biology to biochemistry and medicine, will be a stimulation and motivation for our colleagues in the life sciences. At the same time, we hope that these reflections on microbial adhesion will awake interest in and promote und- standing of the complex processes associated with the glycocalyx and the multif- eted interactions between the host cell and its "guest," as well as the biological consequences resulting from this mutual interplay.

Climate Change and Marine and Freshwater Toxins

Production of toxins by marine and freshwater micro algae has been known for decades. This book compiles evidence on the influence of climate change on the spreading of toxin producing species in aquatic systems.

1. Alicia , Romero Hernández
2. Raúl Oscar , Mocelo

Síntesis y caracterización de fenoxi derivados de la cafeína

Son bien conocidos los efectos que tiene la cafeína (1,3,7trimetilxantina) para la salud, especialmente en el Sistema Nervioso Central, así como el efecto que ejerce en el mal de Parkinson y la enfermedad de Alzheimer. Los humanos han consumido cafeína desde la Edad de Piedra. Los pueblos antiguos descubrieron que masticar la corteza y hojas de ciertas plantas tenían el efecto de aliviar la fatiga, estimular el estado de alerta y elevar el ánimo. En este trabajo presentamos los resultados obtenidos en la síntesis de la 8-bromocafeína mediante el método de bromación que utiliza ácido bromhídrico al 40% y peróxido de hidrógeno al 30%. A partir de este compuesto, se obtuvieron por Sustitución Nucleofílica Aromática (SNA), bajo condiciones de Ullmann cinco derivados de la cafeína como son: 8- fenoxicafeína(I), 8-(2-cloro-5-metilfenoxi)cafeína(II), 8-(2,5 diclorofenoxi)cafeína(III), 8-(4-bromofenoxi)cafeína(IV) y 8-(2-naftoxi)cafeína(V). Estos compuestos de la cafeína fueron sintetizados por primera vez en nuestro laboratorio. Todos los compuestos fueron caracterizados por su temperatura de fusión y sus espectros IR, RMN-1H, RMN-13C y UV.